以Pre C + Core 序列翻译的HBeAg蛋白前体是在胞质中通过翻译后转移到ER还是共翻译转移到ER?

2025-04-07 05:03:05
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回答1:

It dependnts on the sequence of first amino acids of the protein (targeting signals). If the protein is a membrane attached protein or secreted one, translation will take place on the surface of ER after the ribosome attaches to ER. If the protein is not a membrane attached one, translation will be on the free ribosome.

The virual coded protein is translated by cellular translation machinary and will not processed as non-self protein by the infected cell. Only the peptide reaches cell surface with MHC-1, then it is possible the immune cells can recognize it.